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Deep Vein Thrombosis
(Thrombophlebitis)

Definition:
Deep vein thrombosis is a blood clot in a vein deep within the body. Veins are blood vessels. The muscles in the arms and legs contract and help force the blood through the veins back to the heart. A system of valves within the veins helps prevent the blood from flowing backwards.

Deposits of red blood cells and clotting elements in the blood can accumulate in a vein and lead to blood clot formation. Clots usually occur in the legs but can occur in other locations. As the clot grows, it blocks blood flow in the affected vein.

Causes:
Several factors contribute to clot formation, including:

  • Slow blood flow, often due to lying or sitting still for an extended period of time
  • Pooling of blood in a vein, often due to:
    • Immobility
    • Medical conditions
    • Damage to valves in a vein or pressure on the valves, such as occurs during pregnancy
  • Injury to a blood vessel
  • Clotting problems (can occur due to aging or disease)
  • Catheters placed in a vein
Risk Factors:
A risk factor is something that increases your chance of getting a disease or condition.
  • Not moving your body
  • Hospitalization
  • Surgery, especially involving bones or joints
  • Medical conditions such as:
    • Varicose veins
    • Cancer
    • Heart failure
    • Heart attack
    • Inflammatory bowel disease
    • Blood disorders
  • Obesity
  • History of deep vein thrombosis
  • Taking birth control pills or estrogen therapy
  • Pregnancy
Symptoms:
Symptoms occur when:
  • The clot interferes with blood flow in the vein; or
  • Local inflammation occurs; or
  • A clot breaks free and travels to the lungs

Some patients may not experience any symptoms until the clot moves to the lungs, a condition called pulmonary embolism.

Symptoms of deep vein thrombosis may include:

  • Pain
  • Swelling of a limb
  • Tenderness along the vein
  • Warmth
  • Redness, paleness or blueness of the skin of the affected limb
Diagnosis:
The doctor will ask about your symptoms and medical history, and perform a physical exam.

Tests may include:

Duplex Venous Ultrasound – a test that uses sound waves to detect changes in blood flow

Venography – x-rays taken after dye is injected into a small vein, to show areas of normal and abnormal blood flow

Impedance Plethysmography – measures changes in blood volume in the veins as a blood pressure cuff wrapped around the thigh is inflated and deflated

Treatment:
Treatment aims to:
  • Prevent pulmonary embolism
  • Stop the clot from growing
  • Dissolve the clot (sometimes)

Treatments include:

Supportive Care

This may include:

  • Resting in bed
  • Elevating the affected limb above the heart
  • Wearing compression stockings as recommended by your doctor

A recent study among 103 patients recently admitted to the hospital with deep venous thrombosis suggested that strict bed rest may not be necessary. In fact, early ambulation (walking) may be beneficial as long as adequate treatment with heparin (see below) and compression stockings are provided.

Medications
Anticoagulant drugs to prevent additional clot formation include:
  • Heparin injection – fast-acting drug that prevents more clot formation (given for several days)
  • Warfarin (taken by mouth) – slowly prevents more clot formation (usually given for several months)
  • Fibrinolytic enzymes – to help dissolve a major clot. These include:
    • Streptokinase
    • Urokinase
    • TPA
Surgery
In certain situations, doctors may place a filter in the inferior vena cava, a major vein returning blood from the lower body to the heart. The filter may trap any clots that break loose and travel toward the lungs.

Prevention:
General prevention measures include:
  • Not sitting for long periods, such as in a car or airplane or at a computer (Get up frequently and move around.)
  • Not smoking

If you are admitted to the hospital, talk to your doctor about how to prevent blood clots, such as:

  • Getting out of bed and walking as soon as possible during your recovery
  • If you are restricted to bed:
    • Doing range of motion exercises in bed
    • Changing your position at least every two hours
  • Wearing compression stockings, which promotes venous blood flow
  • Taking anticoagulant medication if advised by your doctor
  • Using a pneumatic compression device – a device that uses air to compress your legs and help improve venous blood flow
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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