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Restless Legs Syndrome

Definition :
Restless legs syndrome (RLS) is a condition in which your legs feel extremely uncomfortable while you're sitting or lying down. It usually makes you feel like getting up and moving around. When you do so, the unpleasant feeling of restless legs syndrome goes away.

Restless legs syndrome affects both sexes, can begin at any age and may worsen as you get older. Restless legs syndrome can disrupt sleep — leading to daytime drowsiness — and make traveling difficult.

A number of simple self-care steps and lifestyle changes may benefit you. Medications also help many people with restless legs syndrome.

Causes:
In many cases, no known cause for restless legs syndrome exists. Researchers suspect the condition may be due to an imbalance of the brain chemical dopamine. This chemical sends messages to control muscle movement.

Restless legs syndrome runs in families in up to half of people with RLS, especially if the condition started at an early age. Researchers have identified sites on the chromosomes where genes for RLS may be present.

Stress tends to worsen the symptoms of RLS. Pregnancy or hormonal changes may temporarily worsen RLS signs and symptoms. Some women experience RLS for the first time during pregnancy, especially during their last trimester. However, for most of these women, signs and symptoms usually disappear about a month after delivery.

For the most part, restless legs syndrome isn't related to a serious underlying medical problem. However, RLS sometimes accompanies other conditions, such as :

  • Peripheral neuropathy. This damage to the nerves in your hands and feet is sometimes due to chronic diseases such as diabetes and alcoholism.
  • Iron deficiency. Even without anemia, iron deficiency can cause or worsen restless legs syndrome. If you have a history of bleeding from your stomach or bowels, experience heavy menstrual periods or repeatedly donate blood, you may have iron deficiency.
  • Kidney failure. If you have kidney failure, you also may have iron deficiency. When the kidney fails to function properly, iron stores in your blood can decrease. This, along with other changes in body chemistry, may cause or worsen RLS.

Symptoms :
People typically describe the unpleasant sensations of restless legs syndrome as "deep-seated, creeping, crawling, jittery, tingling, burning or aching" feelings in their calves, thighs, feet or arms. Sometimes the sensations seem to defy description. People usually don't describe the condition as a muscle cramp or numbness. Common characteristics of the signs and symptoms include :

  • Origination during inactivity. The sensation typically begins while you're lying down or sitting for an extended period of time, such as in a car, airplane or movie theater.
  • Relief by movement. The sensation of RLS lessens if you get up and move. People combat the sensation of restless legs in a number of ways — by stretching, jiggling their legs, pacing the floor, exercising or walking. This compelling desire to move is what gives restless legs syndrome its name.
  • Worsening of symptoms in the evening. Symptoms typically are less bothersome during the day and are felt primarily at night.
  • Nighttime leg twitching. RLS is associated with periodic limb movements of sleep (PLMS). Doctors used to call this condition myoclonus, but now they refer to it as PLMS. With PLMS you involuntarily flex and extend your legs while sleeping — without being aware you're doing it — often resulting in a restless night's sleep for your bed partner. Hundreds of these twitching or kicking movements may occur throughout the night. If you have severe RLS, these involuntary kicking movements may also occur while you're awake. PLMS is common in older adults, even without RLS, and doesn't always disrupt sleep. More than four out of five people with RLS also experience PLMS.

Most people with RLS find it difficult to get to sleep or stay asleep. Insomnia may lead to excessive daytime drowsiness, but RLS may prevent you from enjoying a daytime nap.

Although restless legs syndrome doesn't lead to other serious conditions, symptoms can range from bothersome to incapacitating. In fact, it's common for symptoms to fluctuate in severity, and occasionally symptoms disappear for periods of time.

RLS can develop at any age, even during childhood. Many adults who have RLS can recall being told as a child that they had growing pains or can remember parents rubbing their legs to help them fall asleep. The disorder is more common with increasing age.

Diagnosis:
Some people with RLS never seek medical attention because they worry that their symptoms are too difficult to describe or won't be taken seriously. Some doctors wrongly attribute symptoms to nervousness, stress, insomnia or muscle cramps. But restless legs syndrome has received more media attention and focus from the medical community in recent years, making more people aware of the condition.

If you think you may have RLS, consult your family doctor. Doctors diagnose RLS by listening to your description of your symptoms and by reviewing your medical history. Your doctor will ask you questions such as :

  • Do you experience unpleasant or creepy, crawly sensations in your legs, tied to a strong urge to move?
  • Does movement help relieve the sensations?
  • Are you more bothered by these sensations when sitting or at night?
  • Do you often have trouble falling asleep or staying asleep?
  • Have you been told that you jerk your legs, or your arms, when asleep?
  • Is anyone else in your family bothered by restless legs?

There's no blood or lab test specifically for the diagnosis of RLS. Your answers help your doctor clarify whether you have RLS or whether testing is needed to rule out other conditions that may explain your symptoms. Blood tests or muscle or nerve studies may be necessary to pinpoint a cause.

Your doctor may refer you to a sleep specialist for additional evaluation. This may require that you stay overnight at a sleep clinic, where doctors can study your sleep habits closely and check for leg twitching (periodic limb movements) during sleep — a possible sign of restless legs syndrome. However, a diagnosis of RLS usually doesn't require a sleep study.

Treatment:
Sometimes, treating an underlying condition such as iron deficiency or peripheral neuropathy greatly relieves symptoms of RLS. Correcting the iron deficiency may involve taking iron supplements. However, take iron supplements only under medical supervision and after your doctor has checked your blood iron level.

If you have restless legs syndrome without any associated condition, treatment focuses on lifestyle changes and medications. Several prescription medications, most of which were developed to treat other diseases, are available to reduce the restlessness in your legs. These include :

  • Medications for Parkinson's disease. These medications reduce the amount of motion in your legs by affecting the level of the chemical messenger dopamine in your brain. They include pramipexole (Mirapex), ropinirole (Requip) and a combination of carbidopa and levodopa (Sinemet). However, people with RLS are at no greater risk of developing Parkinson's disease than are those without RLS.
  • Opioids. Narcotic medications can relieve mild to severe symptoms, but they may be addicting if used in too high doses. Some examples include codeine, the combination medicine oxycodone and acetaminophen (Percocet, Roxicet), and the combination medicine hydrocodone and acetaminophen (Vicodin, Duocet).
  • Muscle relaxants and sleep medications. This class of medications, known as benzodiazepines, helps you sleep better at night. But these medications don't eliminate the leg sensations, and they may cause daytime drowsiness. Commonly used sedatives for RLS include clonazepam (Klonopin), eszopiclone (Lunesta), ramelteon (Rozerem), temazepam (Restoril, Razapam), zaleplon (Sonata) and zolpidem (Ambien).
  • Medications for epilepsy. Certain epilepsy medications, such as gabapentin (Neurontin), may work well for some people with RLS.

It may take several trials for you and your doctor to find the right medication and dosage for you. A combination of medications may work best.

One caveat with drugs to treat RLS is that sometimes a medication that has worked for you for a while to relieve symptoms becomes ineffective. Or you notice your symptoms returning earlier in the day. For example, if you have been taking your medication at 8 p.m., your symptoms of RLS may start occurring at 6 p.m. This is called augmentation. Your doctor may substitute another medication to combat the problem.

Most of the drugs prescribed to treat RLS aren't recommended for pregnant women. Instead, your doctor may recommend self-care techniques to relieve symptoms. However, if the sensations are particularly bothersome during your last trimester, your doctor may OK the use of pain relievers.

Some medications may worsen symptoms of RLS. These include antinausea drugs, calcium channel blockers (which are used to treat heart conditions) and most antidepressants. Your doctor may recommend that you avoid these medications if possible. However, should you need to take these medications, restless legs can still be controlled by adding drugs that manage the condition.

 
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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